sofos
29-11-11, 02:41
http://gnc.imageg.net/graphics/product_images/pGNC1-11616572dt.jpg
http://usplabsdirect.com/compound20-innercircle-release/warnings-directions-facts.gif
[Dear Inner Circle Member,
The Beta-2 andrenoceptor became legendary virtually overnight when "Clen" hit the scene...
Why? Because if this receptor is activated, it opens up a world of possibilities...
Bigger, Stronger AND Leaner? Ok, Keep Talking...
This receptor is believed to do so by activating the same signaling pathway that powerful anabolic hormones are able to activate – without the sides!
In short, it increases cAMP, which activates Akt signaling, which results in decreased muscle catabolism by decreasing expression of various muscle specific ubiquitin protein ligases (e.g., atrogin-1/MAFbx), which are thought to be responsible for muscle protein degradation...
Furthermore, by working through cAMP and non-cAMP mediated mechanisms, which ultimately results in increased activation of mammalian target of rapamycin (mTOR) signaling – it can result in new lean muscle tissue...
At least one additional potential mechanism is by modifying levels of polyamines, which are compounds thought to play a role in the muscle hypertrophy seen with androgens and Growth Hormone.
In a nutshell, it can potentially prevent muscle from breaking down, while also increasing muscle size. ..
...Do yourself a favor and re-read those last two sentences and let the awesomeness sink in...
The Beta-2 Adrenoreceptor
/QUOTE]
http://usplabsdirect.com/compound20-innercircle-release/2RH1.jpg
[QUOTETry Gaining Fat – I Double-Dog Dare You!
If this weren't enough, by also increasing cAMP in fat tissue, Hormone Sensitive Lipase (HSL) is activated, which stimulates lipolysis and can potentially lead to a reduction of fat mass!
Spillover – Avoid At All Costs!
You see, your body not only has Beta-2 receptors, it also has additional closely-related receptors that most compounds in this class, even Clen, have "spillover" towards – meaning they activate the Beta-2 receptor, but also activate others...
...More is better right? Not in this case...
Related receptors are located on places other than muscle & fat – so that's why some potent Beta-2 agonists (like Clen) come with nasty side effects like extreme jitters, cramping and an overall "feel like crap" day in and day out...
...It's not the Beta-2 activation that causes these issues - it's the spillover...
Additionally, due to this spillover, previous Beta-2 activators were never able to be dosed high enough to enjoy the muscle GAIN (comparable to a mild anabolic) they displayed in animal studies, literally "wasting" this awesome opportunity while getting sliced...
Super-Selective Beta-2 Activity
Of course, many have tried to perfect "super-selective" Beta-2 compounds that could yield the "pros" without the "cons"...
Leave it to Mother Nature to create compounds so selective, scientific data shows it almost exclusively activates Beta-2 in vitro...
...And, what's even more shocking is that we've all consumed these compounds hundreds, maybe thousands, of times in our lives...but never at the amount needed to illicit the desired effects...
Today, that all changes.
A New Category?
Of course, as the results from our beta-testing logs poured in, everyone tried to figure out exactly what Compound 20 was...
...What "category" is it in?
Can't Put This Bad Boy In A Box
Get ready for an entire new category, one that can be used by itself or within your stack, no matter what your goal may be (unless your goal is to get fat and weak!)...Category Awesome
Compound 20 Formula Breakdown
N-Coumaroyldopamine & N-caffeoyldopamine
These particular compounds are found in the cocoa plant (yes chocolate!) and have been shown to have incredibly potent – and selective - beta 2-adrenoceptor agonist properties in vivo...
In fact, their potency in terms of increasing cAMP is greater than that of salbutamol and rivals that of the clenbuterol, often used to, "harden", the physique by increasing muscle and decreasing fat mass (1).
It is believed to do so by activating the same signaling pathway that the powerful anabolic hormones, insulin and IGF-1, are able to activate...
In short, coumaroyldopamine & caffeoyldopamine have demonstrated the ability in vivo to increase cAMP and in turn activate Akt signaling; which may ultimately result in decreased muscle catabolism by decreasing expression of various muscle specific ubiquitin protein ligases (e.g., atrogin-1/MAFbx), which are thought to be responsible for muscle protein degradation.
Furthermore, these incredible compounds may also be able to increase muscle mass by cAMP and non-cAMP mediated mechanism (also involving Akt activation) which ultimately result in increased activation of mammalian target of rapamycin (mTOR) signaling (2,3).
Yet, another mechanism is by potentially modifying polyamine levels (androgens and GH are thought to potentially increase muscle hypertrophy by doing this), it can create yet another mechanism enabling muscle growth (5).
So, the compounds are able to activate pathways involved in the inhibition of skeletal muscle atrophy, while also being able to activate pathways involved in skeletal muscle hypertrophy. In short, it can potentially prevent muscle from being broken down, while also increasing muscle size.
But wait, just like an infomercial, that's not all...
If this weren't enough, by also increasing cAMP in fat tissue, Hormone Sensitive Lipase (HSL), which stimulates lipolysis, can be activated and lead to a reduction of fat mass.
Symplocos Racemosa Extract (standardized for triterpenoids)
This very specific extract was designed to maximize the levels of compounds which can have an additive or even synergistic effect with coumaroyldopamine & caffeoyldopamine by further enhancing their cAMP-increasing effects. It does this in part by inhibiting the degradation of cAMP...
It also goes without saying that this in turn enhances the anti-catabolic/anabolic and lipolytic effects of the coumaroyldopamine & caffeoyldopamine.
In addition, extraction for specific triterpenoid compounds is also expected to further enhance the potential ability of the formulation to increase muscle mass and decrease fat mass by enhancing skeletal muscle insulin/IGF-1 signaling, as was shown with similar compounds in animal models and in vitro (4).
My Future Unborn Baby Understands How Groundbreaking Compound 20 Truly Is...
Incredible by itself, complete game changer when stacked with thermo's or anabolics...
WARNING: Don't expect to be "stimmed" from Compound 20 (we know Clen is a stimulant BECAUSE of spillover to other receptors, not Beta-2 activation.).
Also, don't be surprised if hunger increases on Compound 20; this is a sure sign of TRUE anabolic activity and should be welcomed with open arms as nutrients consumed – even carbs – can become "flagged" by your body for lean mass while stored fat is burned for energy & metabolic processes – incredible Beta-2 "Best Of Both Worlds" action at its finest.]
http://usplabsdirect.com/compound20-innercircle-release/Beta-2chart.jpg
When's The Last Time You Looked In The Mirror And Said "I'd Like To Lose My Muscle And Gain Some Fat!"
Umm, that would be never and exactly why you need to get on Compound 20 NOW with its wide variety of applications:
Lean Bulk – This is the most obvious as this user is already tailoring his diet, training & supplementation to "gain lean mass & get ripped". It goes without saying that Compound 20 is mandatory in this situation.
Cutting –Anyone who begins cutting would give just about anything to keep their muscle while shredding up. Compound-20 stacked with a thermogenic (we are biased, but OxyElite Pro and Compound 20 is simply unbeatable) can have you leaner, harder and stronger than you've ever imagined on a cut...possibly GAINING while revealing those striations. Imagine being pumped all day on a low carbohydrate diet!
Dirty Bulk – If you indulge in fast food & pizza more than you care to admit, you may want to pay attention...No one wants to gain bad weight, even on a dirty bulk. Taking Compound 20 will not only help with your bulk, but can also keep you in check so you look better during the bulk - so you won't have as far to go to be beach-ready.
καλο διαβασμα :green::turtle:
http://usplabsdirect.com/compound20-innercircle-release/warnings-directions-facts.gif
[Dear Inner Circle Member,
The Beta-2 andrenoceptor became legendary virtually overnight when "Clen" hit the scene...
Why? Because if this receptor is activated, it opens up a world of possibilities...
Bigger, Stronger AND Leaner? Ok, Keep Talking...
This receptor is believed to do so by activating the same signaling pathway that powerful anabolic hormones are able to activate – without the sides!
In short, it increases cAMP, which activates Akt signaling, which results in decreased muscle catabolism by decreasing expression of various muscle specific ubiquitin protein ligases (e.g., atrogin-1/MAFbx), which are thought to be responsible for muscle protein degradation...
Furthermore, by working through cAMP and non-cAMP mediated mechanisms, which ultimately results in increased activation of mammalian target of rapamycin (mTOR) signaling – it can result in new lean muscle tissue...
At least one additional potential mechanism is by modifying levels of polyamines, which are compounds thought to play a role in the muscle hypertrophy seen with androgens and Growth Hormone.
In a nutshell, it can potentially prevent muscle from breaking down, while also increasing muscle size. ..
...Do yourself a favor and re-read those last two sentences and let the awesomeness sink in...
The Beta-2 Adrenoreceptor
/QUOTE]
http://usplabsdirect.com/compound20-innercircle-release/2RH1.jpg
[QUOTETry Gaining Fat – I Double-Dog Dare You!
If this weren't enough, by also increasing cAMP in fat tissue, Hormone Sensitive Lipase (HSL) is activated, which stimulates lipolysis and can potentially lead to a reduction of fat mass!
Spillover – Avoid At All Costs!
You see, your body not only has Beta-2 receptors, it also has additional closely-related receptors that most compounds in this class, even Clen, have "spillover" towards – meaning they activate the Beta-2 receptor, but also activate others...
...More is better right? Not in this case...
Related receptors are located on places other than muscle & fat – so that's why some potent Beta-2 agonists (like Clen) come with nasty side effects like extreme jitters, cramping and an overall "feel like crap" day in and day out...
...It's not the Beta-2 activation that causes these issues - it's the spillover...
Additionally, due to this spillover, previous Beta-2 activators were never able to be dosed high enough to enjoy the muscle GAIN (comparable to a mild anabolic) they displayed in animal studies, literally "wasting" this awesome opportunity while getting sliced...
Super-Selective Beta-2 Activity
Of course, many have tried to perfect "super-selective" Beta-2 compounds that could yield the "pros" without the "cons"...
Leave it to Mother Nature to create compounds so selective, scientific data shows it almost exclusively activates Beta-2 in vitro...
...And, what's even more shocking is that we've all consumed these compounds hundreds, maybe thousands, of times in our lives...but never at the amount needed to illicit the desired effects...
Today, that all changes.
A New Category?
Of course, as the results from our beta-testing logs poured in, everyone tried to figure out exactly what Compound 20 was...
...What "category" is it in?
Can't Put This Bad Boy In A Box
Get ready for an entire new category, one that can be used by itself or within your stack, no matter what your goal may be (unless your goal is to get fat and weak!)...Category Awesome
Compound 20 Formula Breakdown
N-Coumaroyldopamine & N-caffeoyldopamine
These particular compounds are found in the cocoa plant (yes chocolate!) and have been shown to have incredibly potent – and selective - beta 2-adrenoceptor agonist properties in vivo...
In fact, their potency in terms of increasing cAMP is greater than that of salbutamol and rivals that of the clenbuterol, often used to, "harden", the physique by increasing muscle and decreasing fat mass (1).
It is believed to do so by activating the same signaling pathway that the powerful anabolic hormones, insulin and IGF-1, are able to activate...
In short, coumaroyldopamine & caffeoyldopamine have demonstrated the ability in vivo to increase cAMP and in turn activate Akt signaling; which may ultimately result in decreased muscle catabolism by decreasing expression of various muscle specific ubiquitin protein ligases (e.g., atrogin-1/MAFbx), which are thought to be responsible for muscle protein degradation.
Furthermore, these incredible compounds may also be able to increase muscle mass by cAMP and non-cAMP mediated mechanism (also involving Akt activation) which ultimately result in increased activation of mammalian target of rapamycin (mTOR) signaling (2,3).
Yet, another mechanism is by potentially modifying polyamine levels (androgens and GH are thought to potentially increase muscle hypertrophy by doing this), it can create yet another mechanism enabling muscle growth (5).
So, the compounds are able to activate pathways involved in the inhibition of skeletal muscle atrophy, while also being able to activate pathways involved in skeletal muscle hypertrophy. In short, it can potentially prevent muscle from being broken down, while also increasing muscle size.
But wait, just like an infomercial, that's not all...
If this weren't enough, by also increasing cAMP in fat tissue, Hormone Sensitive Lipase (HSL), which stimulates lipolysis, can be activated and lead to a reduction of fat mass.
Symplocos Racemosa Extract (standardized for triterpenoids)
This very specific extract was designed to maximize the levels of compounds which can have an additive or even synergistic effect with coumaroyldopamine & caffeoyldopamine by further enhancing their cAMP-increasing effects. It does this in part by inhibiting the degradation of cAMP...
It also goes without saying that this in turn enhances the anti-catabolic/anabolic and lipolytic effects of the coumaroyldopamine & caffeoyldopamine.
In addition, extraction for specific triterpenoid compounds is also expected to further enhance the potential ability of the formulation to increase muscle mass and decrease fat mass by enhancing skeletal muscle insulin/IGF-1 signaling, as was shown with similar compounds in animal models and in vitro (4).
My Future Unborn Baby Understands How Groundbreaking Compound 20 Truly Is...
Incredible by itself, complete game changer when stacked with thermo's or anabolics...
WARNING: Don't expect to be "stimmed" from Compound 20 (we know Clen is a stimulant BECAUSE of spillover to other receptors, not Beta-2 activation.).
Also, don't be surprised if hunger increases on Compound 20; this is a sure sign of TRUE anabolic activity and should be welcomed with open arms as nutrients consumed – even carbs – can become "flagged" by your body for lean mass while stored fat is burned for energy & metabolic processes – incredible Beta-2 "Best Of Both Worlds" action at its finest.]
http://usplabsdirect.com/compound20-innercircle-release/Beta-2chart.jpg
When's The Last Time You Looked In The Mirror And Said "I'd Like To Lose My Muscle And Gain Some Fat!"
Umm, that would be never and exactly why you need to get on Compound 20 NOW with its wide variety of applications:
Lean Bulk – This is the most obvious as this user is already tailoring his diet, training & supplementation to "gain lean mass & get ripped". It goes without saying that Compound 20 is mandatory in this situation.
Cutting –Anyone who begins cutting would give just about anything to keep their muscle while shredding up. Compound-20 stacked with a thermogenic (we are biased, but OxyElite Pro and Compound 20 is simply unbeatable) can have you leaner, harder and stronger than you've ever imagined on a cut...possibly GAINING while revealing those striations. Imagine being pumped all day on a low carbohydrate diet!
Dirty Bulk – If you indulge in fast food & pizza more than you care to admit, you may want to pay attention...No one wants to gain bad weight, even on a dirty bulk. Taking Compound 20 will not only help with your bulk, but can also keep you in check so you look better during the bulk - so you won't have as far to go to be beach-ready.
καλο διαβασμα :green::turtle: